I have the code below where I'm trying to play a note in mac from a python application. Unfortunately I have noticed that the only way that the sound is audible is when garageband is opened.

Is there a way to play midi sound without having another application such as garageband opened?

I know this is possible in java.

import time
import rtmidi as rtmidi

def open_midi():
    
        midiout = rtmidi.MidiOut()
        available_ports = midiout.get_ports()
    
        if available_ports:
            print("Available ports")
            midiout.open_port(0)
        else:
            print("Opening virtual ports")
            midiout.open_virtual_port("My virtual output")
        return midiout
    def play(note):
        with open_midi() as midiout:
            while True:
                note_on = [0x90, note, 112] # channel 1, middle C, velocity 112
                note_off = [0x80, note, 0]
                midiout.send_message(note_on)
                time.sleep(0.5)
                midiout.send_message(note_off)
                time.sleep(0.1)
    
        del midiout
    play(60)