Q.1 Which of the following drugs is classified as an alkylating agent?
Methotrexate
Cyclophosphamide
5-Fluorouracil
Doxorubicin
Explanation - Cyclophosphamide works by adding alkyl groups to DNA, leading to cross-linking and inhibition of DNA replication.
Correct answer is: Cyclophosphamide
Q.2 Methotrexate primarily inhibits which enzyme?
Dihydrofolate reductase
Topoisomerase II
Thymidylate synthase
DNA polymerase
Explanation - Methotrexate inhibits dihydrofolate reductase, preventing the formation of tetrahydrofolate and thus blocking DNA synthesis.
Correct answer is: Dihydrofolate reductase
Q.3 Which drug is considered a topoisomerase II inhibitor?
Etoposide
Vincristine
Cisplatin
Bleomycin
Explanation - Etoposide inhibits topoisomerase II, leading to DNA strand breaks and apoptosis of cancer cells.
Correct answer is: Etoposide
Q.4 Paclitaxel acts by:
Inhibiting microtubule depolymerization
Cross-linking DNA
Inhibiting thymidylate synthase
Blocking estrogen receptors
Explanation - Paclitaxel stabilizes microtubules, preventing their depolymerization, which inhibits mitosis and induces apoptosis.
Correct answer is: Inhibiting microtubule depolymerization
Q.5 Which antineoplastic agent is a monoclonal antibody against CD20?
Rituximab
Trastuzumab
Bevacizumab
Cetuximab
Explanation - Rituximab targets CD20 on B-cells, leading to their destruction via immune-mediated mechanisms.
Correct answer is: Rituximab
Q.6 5-Fluorouracil (5-FU) is primarily used to inhibit which process?
RNA synthesis
DNA synthesis
Protein synthesis
Microtubule formation
Explanation - 5-FU is a pyrimidine analog that inhibits thymidylate synthase, reducing dTMP and thereby blocking DNA synthesis.
Correct answer is: DNA synthesis
Q.7 Imatinib is effective in chronic myeloid leukemia because it inhibits:
BCR-ABL tyrosine kinase
EGFR receptor
VEGF receptor
mTOR kinase
Explanation - Imatinib specifically inhibits the BCR-ABL fusion protein, which drives uncontrolled proliferation in CML.
Correct answer is: BCR-ABL tyrosine kinase
Q.8 Bleomycin exerts its antitumor effect by:
Inducing DNA strand breaks
Inhibiting dihydrofolate reductase
Blocking estrogen receptors
Stabilizing microtubules
Explanation - Bleomycin generates free radicals that cause single- and double-strand breaks in DNA, leading to cell death.
Correct answer is: Inducing DNA strand breaks
Q.9 Tamoxifen is an example of which class of antineoplastic agent?
Alkylating agent
Anti-estrogen
Topoisomerase inhibitor
Antimetabolite
Explanation - Tamoxifen binds to estrogen receptors in breast tissue, blocking estrogen-mediated growth of cancer cells.
Correct answer is: Anti-estrogen
Q.10 Cisplatin primarily acts by:
Alkylating DNA
Cross-linking DNA
Inhibiting microtubules
Blocking folate metabolism
Explanation - Cisplatin forms intra- and inter-strand DNA cross-links, preventing DNA replication and transcription.
Correct answer is: Cross-linking DNA
Q.11 Vincristine is associated with which major side effect?
Peripheral neuropathy
Myelosuppression
Cardiotoxicity
Pulmonary fibrosis
Explanation - Vincristine inhibits microtubule formation in neurons, leading to peripheral neuropathy as a common adverse effect.
Correct answer is: Peripheral neuropathy
Q.12 Which drug is a proteasome inhibitor used in multiple myeloma?
Bortezomib
Doxorubicin
Cyclophosphamide
Methotrexate
Explanation - Bortezomib inhibits the 26S proteasome, leading to apoptosis in multiple myeloma cells.
Correct answer is: Bortezomib
Q.13 Which antineoplastic agent is known for causing cardiotoxicity?
Doxorubicin
5-Fluorouracil
Methotrexate
Paclitaxel
Explanation - Doxorubicin generates free radicals that damage cardiac myocytes, potentially leading to cardiomyopathy.
Correct answer is: Doxorubicin
Q.14 Which class of drugs inhibits DNA synthesis by mimicking purine or pyrimidine bases?
Alkylating agents
Antimetabolites
Mitotic inhibitors
Topoisomerase inhibitors
Explanation - Antimetabolites resemble natural nucleotides and interfere with DNA and RNA synthesis during cell division.
Correct answer is: Antimetabolites
Q.15 Which of the following is a VEGF inhibitor used in cancer therapy?
Bevacizumab
Trastuzumab
Rituximab
Etoposide
Explanation - Bevacizumab is a monoclonal antibody that binds VEGF, preventing angiogenesis in tumors.
Correct answer is: Bevacizumab
Q.16 Which drug is specifically used in HER2-positive breast cancer?
Trastuzumab
Rituximab
Paclitaxel
Cisplatin
Explanation - Trastuzumab is a monoclonal antibody targeting HER2 receptors on breast cancer cells, inhibiting proliferation.
Correct answer is: Trastuzumab
Q.17 Which antineoplastic agent is known for causing pulmonary fibrosis?
Bleomycin
Doxorubicin
Methotrexate
Vincristine
Explanation - Bleomycin accumulates in the lungs and can induce free radical-mediated damage, leading to pulmonary fibrosis.
Correct answer is: Bleomycin
Q.18 Which of the following is a cytarabine analog used in leukemia?
Cytarabine
Fludarabine
Gemcitabine
Methotrexate
Explanation - Cytarabine is a pyrimidine analog incorporated into DNA, inhibiting DNA polymerase and halting replication.
Correct answer is: Cytarabine
Q.19 Which antineoplastic agent is known as a mitotic spindle poison?
Vinblastine
Cisplatin
Methotrexate
5-Fluorouracil
Explanation - Vinblastine binds tubulin, inhibiting microtubule formation, arresting cells in metaphase, and inducing apoptosis.
Correct answer is: Vinblastine
Q.20 L-asparaginase is primarily used in which type of cancer?
Acute lymphoblastic leukemia
Breast cancer
Lung cancer
Prostate cancer
Explanation - L-asparaginase depletes asparagine, an amino acid necessary for leukemia cells, leading to selective cytotoxicity.
Correct answer is: Acute lymphoblastic leukemia
Q.21 Which antineoplastic agent is a folate analog?
Methotrexate
Cisplatin
Doxorubicin
Paclitaxel
Explanation - Methotrexate resembles folic acid and competitively inhibits dihydrofolate reductase, disrupting DNA synthesis.
Correct answer is: Methotrexate
Q.22 Which of the following drugs inhibits ribonucleotide reductase?
Hydroxyurea
Methotrexate
5-Fluorouracil
Vincristine
Explanation - Hydroxyurea inhibits ribonucleotide reductase, reducing deoxyribonucleotide formation and blocking DNA synthesis.
Correct answer is: Hydroxyurea
Q.23 Which antineoplastic drug is associated with nephrotoxicity?
Cisplatin
Vincristine
Methotrexate
Bleomycin
Explanation - Cisplatin is excreted by the kidneys and can damage renal tubular cells, leading to nephrotoxicity.
Correct answer is: Cisplatin
Q.24 Which drug is a nucleoside analog used in hematologic malignancies?
Fludarabine
Paclitaxel
Cyclophosphamide
Doxorubicin
Explanation - Fludarabine is a purine nucleoside analog that interferes with DNA synthesis, particularly in lymphoid malignancies.
Correct answer is: Fludarabine
Q.25 Which of the following drugs is classified as an anthracycline?
Doxorubicin
Cisplatin
Vincristine
Methotrexate
Explanation - Doxorubicin is an anthracycline that intercalates into DNA, inhibits topoisomerase II, and generates free radicals.
Correct answer is: Doxorubicin